Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions: In vitro and in vivo characterization
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چکیده
منابع مشابه
Genipin crosslinked gelatin nanofibers for tissue engineering.
summary The objective of this study was to enhance the mechanical and thermo-mechanical properties of electrospun gelatin nanofibers, while maintaining their good bioactivity. In this work, genipin was used as crosslinker to achieve this goal. Electrospun gelatin nanofibers were crosslinked with genipin vapor at room temperature for 0 h, 6 h, 12 h, 24 h, 48 h and 72 h. The morphologies of the c...
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Objectives: Postsurgical adhesion is one of the common complications after surgery. Some anti-adhesion barriers are commercially available which are not customary used by physicians as much as expected because of ineffectiveness. Recently, nanofibers have been introduced as anti-adhesion barriers with t...
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Leptospirosis is one of the most prevalent zoonotic diseases worldwide. Currently, multivalent whole-cell leptospiral vaccines can induce protection against leptospirosis. Therefore, preparation and formulation of new generations of vaccines that can stimulate long-term immunity for leptospirosis control are essential. The aim of this study was to prepare and characterize alginate microspheres ...
متن کاملBiodegradable microspheres based on gelatin-porcine mucin admixtures: in vitro and in vivo delivery studies.
Soluble mucus glycoprotein (S-mucin) processed from the small intestines (ileal region) of freshly slaughtered pigs via homogenization, dialysis, centrifugation and lyophilization and their admixtures with type B gelatin were used to prepare cefaclor-loaded microspheres by the emulsification-crosslinking method. The microspheres were evaluated for the in vitro delivery of cefaclor in both simul...
متن کاملGenipin-Modified Gelatin: Preparation, Characterization, and Application as a Filler for Leather
Genipin, an iridoid compound extracted from gardenia fruits (Gardenia jasminoides Ellis) is a natural crosslinking agent. Because of its low cytotoxicity, genipin is increasingly used to replace both glutaraldehyde and formaldehyde as a crosslinker for proteins. Researchers have in recent years successfully demonstrated the effective use of genipin in the modification of gelatin, particularly f...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2016
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2016.04.012